![]() noted that an increase of model parameterisation also increases parameter trade-off, and potentially limits the parameter estimation accuracy and predictive capability of the model. However, these complex models often requires additional clinical protocols and/or invasive measurement and they are less clinically feasible. Complex models can describe the respiratory system in more detail compared to simpler models. The respiratory system can be modelled differently, ranging from a simple single compartment lung model to a complex airway branching model. This issue significantly limits the use of model-based methods, as more patients are ventilated with partial ventilation or SB MV modes. Thus, estimating respiratory mechanics to guide MV is currently limited to patients who are fully sedated, and is often less reliable when the patient is semi-conscious, awake and breathing spontaneously. In particular, the patient’s own breathing effort obscures model-based observation of the mechanics of the sedated, passive lung. However, for spontaneously breathing (SB) patients, additional equipment or invasive clinical manoeuvres are required to determine the patient’s true respiratory mechanics. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Įstimation of patient-specific respiratory mechanics has shown promising results in optimising mechanical ventilation (MV) on a patient-specific basis. Data may be requested from the corresponding author ( This work was supported in part by the FNRS 474 (Belgium), the FRST (New Zealand), the University of Liege, the 475, Belgian French Community (ARC-Academie Wallonie Europe). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: Ethical restrictions prevent public sharing of data. ![]() Received: JAccepted: NovemPublished: January 22, 2015Ĭopyright: © 2015 Chiew et al. Technion-Israel Institute of Technology, ISRAEL (2015) Time-Varying Respiratory System Elastance: A Physiological Model for Patients Who Are Spontaneously Breathing. Citation: Chiew YS, Pretty C, Docherty PD, Lambermont B, Shaw GM, Desaive T, et al.
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